Discuss at least three symptoms caused by physiologic changes and consequences of GERD and peptic ulcer disease (PUD). Discuss the findings for each disorder, comparing and contrasting symptoms, lab findings, and possible etiologies. Discuss how pharmaceutical treatments are designed to alleviate those symptoms. What are the risks and benefits of these treatments? What are potential drug interactions with these medications?

Locate at least one scholarly source that addresses this topic in support of your perspective in a 250-word initial post. Two peer response posts should include at a minimum 100 words, to extend the discussion.

Expert Answer and Explanation

GERD and Peptic Ulcer Disease (PUD)

Symptoms

Both gastroesophageal reflux (GERD) and peptic ulcer disease (PUD) are disorders related to high acid levels in the gut system. A person experiencing GERD can demonstrate symptoms such as a burning sensation in the chest area, that frequents after eating or at night (Wei et al., 2020). Additional symptoms include regurgitation of food, chest pain, and difficulties in swallowing. On the other hand, symptoms associated with PUD include a burning sensation in the stomach intolerance to fatty foods, nausea, bloating, feeling of fulness, and occasional heartburn.

Finding for Each Disorder

The symptoms of GERD can be explained due to the regurgitation or reflux of food from the stomach to the esophagus leading to a burning sensation to the outer lining. With PUD, the burning feeling in the stomach is a result of painful sores usually attributed to Helicobacter pylori (H. pylori) (Wei et al., 2020). While the two disorders are caused by acid fluctuation, they have different symptoms due to the mechanism in which they present or regions that are affected.

Impact of Pharmaceutical Treatment

Histamine-2 receptor blocker is a pharmaceutical treatment for PUD as they get rapidly absorbed by the body. The medication works by suppressing the production of hydrochloric acid in the stomach which inhibits the symptoms of the disorder (Park et al., 2020). The suppression only lasts a few hours which is essential to help mitigate the pain. The treatment can also be used when dealing with GERD which also makes use of antacids and ranitidine. These medications also which work the same way as the Histamine-2 receptor blockers by suppressing the production of stomach acid (Park et al., 2020). The inhibition of acid production helps the gut system to heal before the acid continues to be released again. In general, there is a low potential drug-drug interaction rate for the medication.

References

Park, J. H., Lee, J., Yu, S. Y., Jung, J. H., Han, K., Kim, D. H., & Rhee, J. (2020). Comparing Proton Pump Inhibitors With Histamin-2 Receptor Blockers Regarding The Risk Of Osteoporotic Fractures: A Nested Case-Control Study Of More Than 350,000 Korean Patients With GERD And Peptic Ulcer Disease. BMC Geriatrics, 20(1), 1-11.

Wei, C. Y., Tzeng, I., Lin, M. C., Yeh, Y. H., Hsu, C. Y., & Kung, W. M. (2020). Risks Of Sulpiride-Induced Parkinsonism In Peptic Ulcer And Gastroesophageal Reflux Disease Patients In Taiwan: A Nationwide Population-Based Study. Frontiers In Pharmacology, 11, 433.

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